Abstract HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis.Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef.Using purified recombinant proteins in pull-down assays and by co-immunoprecipitation assays w

PurposeTo explore the clinical phenotype and genetic defects of families with congenital aniridia.MethodsFour Chinese families with aniridia were enrolled in this study.The detailed ocular presentations of the patients were recorded.Whole exome sequencing (BGI MGIEasy V4 chip) was used to detect the gene mutation.Sanger sequencing was performed to

Humanitarian immigrants and orly artificial sweetener refugees face multiple adjustment tasks and post-settlement support services concentrated in metropolitan areas play an important role.As part of an ongoing commitment, the Australian Government has increasingly supported resettlement in rural and regional areas of the country.Drawing on the exp

Between 12 and 19 July 2021, a quasi-stationary atmospheric low-pressure system named Bernd caused intense precipitation on already-saturated soil, resulting in severe flooding in Germany, Belgium, and the Netherlands.The Ahr Valley in Rhineland-Palatinate was particularly affected, with approximately 42 000 residents impacted, around 8800 building

Female endoparasitoid wasps usually inject venom into hosts to suppress their immune response and ensure offspring development.However, the parasitoids ability to evolve hdw1620dnpk towards increased success on a given host simultaneously with the evolution of the composition of its venom has never been demonstrated.Here, we designed an experimenta